The cloud is petty much a motorway, don’t drive like with a manual gear car.
Simply put: keep it simple…
Automate things from the beginning
Use cloud portals/dashboards for prototyping and implement an IaC with CICD and DevOps approach as soon as you have things clear
More than a few weeks for deploying a MVP? Review your principles, perhaps there is something that can be done smartly.
High availability and disaster recovery by default even for small budgets
In the cloud, you can create quickly and easily many resources in different cloud providers and regions in a matter of minutes or a few hours. Use all those potential to create HA and DR solutions from the beginning.
Don’t fear the latency so much
Use caches, compression, deltas, replication, event driven and whatever other cloud capabilities that can help you make solutions resilient to latency.
Test, Test, Test
Always test, test almost everything, automate testing, even test the testing.